The study examines private health care finance and infant mortality rate in Nigeria from 1980- 2020. To facilitate this study, data were sourced from World Bank database and analyzed using the ordinary least square (OLS) regression method. The result revealed that private health expenditure, per capita income and percentage of children immunize against diseases and infections are significant factors that affect infant mortality rate in Nigeria. It was therefore recommended among others that there is need for teamwork amongst public and private sectors in providing quality and quantitative health facility to meet the demand of Nigerians and this will in turn, decrease the problem on the government. Also, government should intensify immunization programs and activities to help protect infant from being infected with diseases